The development of a Dream of Red Mansions as a humanistic quality course in universities is one of the important ways to realize the research results benefit the public. The article first expounds the two preconditions for the construction of the humanistic quality course of A Dream of Red Mansions, namely, to select college students and take the text of the Red Mansions as a platform to accumulate cultural knowledge, so as to realize the purpose of inheriting and developing traditional Chinese culture.Secondly, the basis points of the concept of humanistic quality, the setting of teaching objectives, the choice of teaching methods, the application of teaching means and the reserve of teaching resources are analyzed. Finally, we put forward the curriculum construction concept of “one mind, three reading and four teaching”, and explain the internal logical relationship between the elements in the curriculum construction concept and each region respectively, which provides theoretical reference and development ideas for the construction of a Dream of Red Mansions as a university humanistic quality course.