Compared with general higher education, higher vocational education places more emphasis on students’ practical ability rather than theoretical ability. The integration of production and education and school-enterprise cooperation are the essence and basic mode of vocational education training high-quality technical and technical talents. However, for most vocational colleges and enterprises, the integration of production and education and school-enterprise cooperation are nothing more than the traditional cooperation model of “school learning, enterprise internship”. To break this model, schools and companies should start collaborative design from the start of enrollment. The talent training model is linked to the needs of the company. Schools and companies share teaching and assessment. The industry’s first-line needs are guided and experience is the cornerstone to effectively promote production-based School-enterprise cooperation in the context of teaching integration. One College has explored and practiced the school-enterprise cooperation model of “six collaborations and two mutual learnings”, and the quality of talent training has been significantly improved, realizing a win-win situation for schools and enterprises.